Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Resting Potential Decay01:15

Resting Potential Decay

4.9K
The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane...
4.9K
MOS Capacitor01:25

MOS Capacitor

721
A Metal-Oxide-Semiconductor (MOS) capacitor is a fundamental structure used extensively in semiconductor device technology, particularly in the fabrication of integrated circuits and MOSFETs (metal-oxide-semiconductor field-effect transistors). The MOS capacitor consists of three layers: a metal gate, a dielectric oxide, and a semiconductor substrate.
The metal gate is typically made from highly conductive materials such as aluminum or polysilicon. Beneath the metal gate lies a thin layer of...
721
Oscillations In An LC Circuit01:30

Oscillations In An LC Circuit

2.2K
An idealized LC circuit of zero resistance can oscillate without any source of emf by shifting the energy stored in the circuit between the electric and magnetic fields. In such an LC circuit, if the capacitor contains a charge q before the switch is closed, then all the energy of the circuit is initially stored in the electric field of the capacitor. This energy is given by
2.2K
Action Potentials01:41

Action Potentials

130.3K
Overview
130.3K
Resting Membrane Potential01:24

Resting Membrane Potential

18.3K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
18.3K
The Resting Membrane Potential01:21

The Resting Membrane Potential

131.5K
Overview
131.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tuning excitatory input to fast-spiking parvalbumin-positive interneurons: a lever for plasticity and hyperexcitability across the lifespan.

Frontiers in synaptic neuroscience·2026
Same author

Circadian Changes in CA1 LTP Are Driven by Shifts in Excitation-Inhibition Balance and Reverse Direction after Puberty in Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Rapid plasticity of default-mode local network architectures following adult-onset blindness.

Cell reports·2026
Same author

Parallel circadian-like oscillations in LTP and excitation inhibition balance in mouse CA1 reverse direction after puberty.

bioRxiv : the preprint server for biology·2025
Same author

Three-Dimensional (3D) Printing for Left Atrial Appendage Occlusion Device Sizing: A Systematic Review and Comparative Analysis.

Cureus·2025
Same author

NPTX2 transfection improves synaptic E/I balance and performance in learning impaired aged rats.

Progress in neurobiology·2025

Related Experiment Video

Updated: Jun 12, 2025

Patch-clamp Capacitance Measurements and Ca2+ Imaging at Single Nerve Terminals in Retinal Slices
09:16

Patch-clamp Capacitance Measurements and Ca2+ Imaging at Single Nerve Terminals in Retinal Slices

Published on: January 19, 2012

18.1K

Daily oscillations of neuronal membrane capacitance.

Daniel Severin1, Cristián Moreno1, Trinh Tran1

  • 1Johns Hopkins Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Rm. 350 Dunning Hall, 3400 N. Charles St., Baltimore, MD 21218, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.

Cell Reports
|September 19, 2024
PubMed
Summary

Neuronal membrane capacitance, previously thought stable, fluctuates daily in excitatory neurons. This daily change in capacitance impacts synaptic integration time windows in pyramidal cells.

Keywords:
CP: NeuroscienceCircadiancapacitancecortexelectrophysiologygranule cellshippocampusoscillatorspyramidal cells

More Related Videos

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises
13:56

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises

Published on: January 18, 2011

22.7K
Introduction to Solid Supported Membrane Based Electrophysiology
19:56

Introduction to Solid Supported Membrane Based Electrophysiology

Published on: May 11, 2013

15.1K

Related Experiment Videos

Last Updated: Jun 12, 2025

Patch-clamp Capacitance Measurements and Ca2+ Imaging at Single Nerve Terminals in Retinal Slices
09:16

Patch-clamp Capacitance Measurements and Ca2+ Imaging at Single Nerve Terminals in Retinal Slices

Published on: January 19, 2012

18.1K
Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises
13:56

Modeling Biological Membranes with Circuit Boards and Measuring Electrical Signals in Axons: Student Laboratory Exercises

Published on: January 18, 2011

22.7K
Introduction to Solid Supported Membrane Based Electrophysiology
19:56

Introduction to Solid Supported Membrane Based Electrophysiology

Published on: May 11, 2013

15.1K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Electrophysiology

Background:

  • Neuronal membrane capacitance influences key electrical properties like synaptic integration and action potential propagation.
  • It is generally considered a stable, non-regulated cellular parameter, with changes typically linked to slow developmental processes.

Purpose of the Study:

  • To investigate whether neuronal membrane capacitance exhibits dynamic changes within a daily cycle.
  • To determine if these changes differ between excitatory and inhibitory neuronal types.

Main Methods:

  • Electrophysiological recordings were performed on mouse primary visual cortex pyramidal cells and hippocampal granule cells.
  • Capacitance measurements were taken at different time points across a daily light-dark cycle.
  • Cortical parvalbumin-expressing inhibitory interneurons were also studied for comparison.

Main Results:

  • Excitatory neurons (pyramidal and granule cells) showed significant, nearly 2-fold daily fluctuations in membrane capacitance.
  • These capacitance changes were not observed in inhibitory parvalbumin-expressing interneurons.
  • The time window for synaptic integration in pyramidal cells varied in correlation with capacitance fluctuations.

Conclusions:

  • Neuronal membrane capacitance is dynamically regulated on a daily timescale in specific excitatory neuronal populations.
  • This daily rhythm in capacitance may play a role in modulating neuronal excitability and synaptic integration.
  • Inhibitory interneurons appear to maintain a more stable membrane capacitance throughout the daily cycle.