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Association between DEFB1 polymorphisms and periodontitis: a meta-analysis.
Die Pharmazie
|July 11, 2019
Summary
The DEFB1-G1654A gene polymorphism is linked to increased periodontitis risk. Other DEFB1 gene variants showed no significant association with this common gum disease.
Area of Science:
- Genetics
- Periodontology
- Molecular Biology
Background:
- Previous studies suggest a link between DEFB1 gene polymorphisms and periodontitis.
- However, existing research presents inconsistent findings regarding this association.
Purpose of the Study:
- To conduct a meta-analysis exploring the association between DEFB1 gene polymorphisms and periodontitis.
- To clarify the role of specific DEFB1 variants in periodontitis development and progression.
Main Methods:
- A systematic literature search was performed across PubMed, Embase, Springer, and Cochrane Library for relevant case-control studies.
- Nine studies with 4113 patients and 2373 controls were included after applying predefined criteria.
- Study quality was assessed using the Newcastle-Ottawa Scale (NOS), and meta-analysis was conducted using R software.
Main Results:
- The DEFB1-G1654A polymorphism showed a significant association with periodontitis across various genetic models (e.g., A vs. G, AA vs. GG).
- No significant associations were found between DEFB1 rs11362, rs1799946, rs1800972 variants and periodontitis.
- Sensitivity analysis confirmed the robustness of the findings and indicated no significant publication bias.
Conclusions:
- The DEFB1-G1654A polymorphism is identified as a potential genetic susceptibility factor for periodontitis.
- Other investigated DEFB1 gene polymorphisms (rs11362, rs1799946, rs1800972) do not appear to be significantly associated with periodontitis risk.
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