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Obstructive sleep apnoea in a patient with chronic lymphocytic leukaemia

Gregory Paul Stimac¹, Asefa Jejaw Mekonnen²

¹Medicine, Georgetown University School of Medicine, Washington, DC, USA.

BMJ Case Reports

|July 11, 2019

Abstract:

A 69-year-old Caucasian woman presented with chronic lymphocytic leukaemia (CLL; stage 1-Rai System), significant oropharyngeal lymphoid enlargement, snoring and fatigue. Overnight polysomnography revealed moderately severe obstructive sleep apnoea (OSA), which was managed successfully with oral appliance therapy with resolution of snoring and daytime fatigue. Structural abnormalities of the upper airways are known to cause OSA. Airway narrowing can result from bony structural abnormalities, nasopharyngeal growth, soft tissue redundancy, macroglossia, malignant and benign growth of the upper aero-digestive tract, and adenotonsilar enlargement. Clinicians should be encouraged to consider a diagnosis of OSA in patients with CLL when they present with symptoms of worsening fatigue.

Keywords:

cancer—see oncology ear, nose and throat/otolaryngology haematology (incl blood transfusion)oncology

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