Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Truncation in Survival Analysis01:09

Truncation in Survival Analysis

591
Truncation in survival analysis refers to the exclusion of individuals or events from the dataset based on specific criteria related to the time of the event. This exclusion can happen in two primary forms: left truncation and right truncation.
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
591
Testes: Histology01:27

Testes: Histology

2.8K
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
2.8K
Complementation Tests00:49

Complementation Tests

6.1K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.1K
Testes: Gross Anatomy01:19

Testes: Gross Anatomy

5.7K
The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
5.7K
Significance Testing: Overview01:04

Significance Testing: Overview

11.6K
Significance testing is a set of statistical methods used to test whether a claim about a parameter is valid. In analytical chemistry, significance testing is used primarily to determine whether the difference between two values comes from determinate or random errors. The effect of a particular change in the measurement protocol, analyst, or sample itself can cause a deviation from the expected result. In the case of a suspected deviation/outlier, we need to be able to confirm mathematically...
11.6K
Testing Water Quality01:14

Testing Water Quality

378
When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
378

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Group sequential design for randomized trials using "first hitting time" model.

Statistics in medicine·2022
Same author

Sample size adaptations and evaluation of pediatric study interpretability.

Statistics in medicine·2021
Same author

Methods for Employing Information About Uncertainty of Ascertainment of Events in Clinical Trials.

Therapeutic innovation & regulatory science·2020
Same author

Familywise and per-family error rates of multiple comparison procedures.

Statistics in medicine·2019
Same journal

Causally-interpretable random-effects meta-analysis.

Biometrics·2026
Same journal

Statistical inference for mean function of partially observed functional time series.

Biometrics·2026
Same journal

Subgroup identification via Interaction Tree and Mixed Model for Repeated Measures with application to Alzheimer's disease.

Biometrics·2026
Same journal

Finite mixtures of linear quantile regressions with concomitant variables: a solution to endogeneity in longitudinal data modeling.

Biometrics·2026
Same journal

Discussion on "INTACT: a method for integration of longitudinal physical activity data from multiple sources" by Jingru Zhang, Erjia Cui, Hongzhe Li, and Haochang Shou.

Biometrics·2026
Same journal

A Bayesian phase I/II platform design with data augmentation accounting for delayed outcomes.

Biometrics·2026
See all related articles

Related Experiment Video

Updated: Jan 22, 2026

Small Molecule Screening and Toxicity Testing in Early-stage Zebrafish Larvae
02:52

Small Molecule Screening and Toxicity Testing in Early-stage Zebrafish Larvae

Published on: March 7, 2025

2.0K

Truncated Simes tests.

John Lawrence1

  • 1CDER/Division of Biometrics, US Food and Drug Admin, Silver Spring, Maryland.

Biometrics
|July 11, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces truncated Simes

Keywords:
closed test proceduresfamilywise error ratemultiple comparisonsmultivariate total positivity

More Related Videos

Computerized Adaptive Testing System of Functional Assessment of Stroke
05:21

Computerized Adaptive Testing System of Functional Assessment of Stroke

Published on: January 7, 2019

6.3K
The Synthesis of [Sn10SiSiMe334]2- Using a Metastable SnI Halide Solution Synthesized via a Co-condensation Technique
12:43

The Synthesis of [Sn10SiSiMe334]2- Using a Metastable SnI Halide Solution Synthesized via a Co-condensation Technique

Published on: November 28, 2016

9.1K

Related Experiment Videos

Last Updated: Jan 22, 2026

Small Molecule Screening and Toxicity Testing in Early-stage Zebrafish Larvae
02:52

Small Molecule Screening and Toxicity Testing in Early-stage Zebrafish Larvae

Published on: March 7, 2025

2.0K
Computerized Adaptive Testing System of Functional Assessment of Stroke
05:21

Computerized Adaptive Testing System of Functional Assessment of Stroke

Published on: January 7, 2019

6.3K
The Synthesis of [Sn10SiSiMe334]2- Using a Metastable SnI Halide Solution Synthesized via a Co-condensation Technique
12:43

The Synthesis of [Sn10SiSiMe334]2- Using a Metastable SnI Halide Solution Synthesized via a Co-condensation Technique

Published on: November 28, 2016

9.1K

Area of Science:

  • Statistics
  • Statistical hypothesis testing

Background:

  • The one-sided Simes' test error rate is controlled under multivariate totally positive of order 2 (MTP2) distributions, but not universally.
  • The two-sided Simes' test offers broader error rate control when coordinate absolute values follow an MTP2 distribution.

Purpose of the Study:

  • To mathematically prove that truncated Simes' tests can control the one-sided error rate at level α.
  • To compare the performance of these truncated tests against established procedures like Holm, Hochberg, and Hommel.

Main Methods:

  • Mathematical proof of error rate control for truncated Simes' tests.
  • Comparative analysis of truncated tests with Holm, Hochberg, and Hommel procedures under multivariate normal distributions.

Main Results:

  • Demonstrated that truncated Simes' tests control the one-sided error rate at level α when the coordinate absolute value controls the error rate at level 2α.
  • Provided comparisons highlighting scenarios where truncated tests perform similarly to or differently from other multiple testing procedures.

Conclusions:

  • Truncated Simes' tests offer a viable alternative for controlling one-sided error rates in specific statistical scenarios.
  • The findings contribute to the understanding of multiple testing procedures and their error rate control properties.