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Development of computational model for cell dose and DNA damage quantification of multicellular system
Ruirui Liu1,2, Tianyu Zhao2, Maciej H Swat3
1School of Nuclear Science and Engineering, Oregon State University, Corvallis, OR, USA.
International Journal of Radiation Biology
|July 11, 2019
Summary
This study introduces a computational model to simulate radiation transport in multicellular systems, quantifying cellular dose and DNA damage. The model aids in understanding radiation effects on tissues, crucial for radiobiology research.
Area of Science:
- Radiation biology
- Computational modeling
- Biophysics
Background:
- Accurate quantification of cellular dose and DNA damage is essential for understanding radiation effects.
- Existing radiobiological experiments face challenges in precisely measuring these parameters at the cellular level.
Purpose of the Study:
- To develop a computational model for simulating radiation transport in multicellular systems.
- To quantify the distribution of cellular dose and DNA damage (specifically, double-strand breaks) within these systems.
Main Methods:
- Utilized the Geant4 open-source radiation transport package with Geant4-DNA physics.
- Developed a program, CellMaker, to create 2D and 3D computational multicellular systems.
- Simulated radiation transport to determine cellular dose and double-strand break yield.
Main Results:
- The model successfully quantifies both cellular dose and DNA damage simultaneously.
- Provides a method to estimate cellular dose and DNA damage, overcoming experimental limitations.
Conclusions:
- This preliminary study presents a viable computational approach for simulating cellular dose and DNA damage.
- Offers a roadmap for developing a comprehensive toolkit for radiobiological simulations of multicellular tissues.
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