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Assessment of HLADP gene rs3128917 and rs9380343 polymorphisms in chronic HBV infection

Ersin Akgöllü1

  • 1Department of Gastroenterology, Çukurova University School of Medicine, Adana, Turkey.

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|July 11, 2019
PubMed

Insights

The human leukocyte antigen (HLA) rs9380343 gene variant is linked to persistent Hepatitis B virus (HBV) infection. This genetic factor increases the risk of chronic HBV, particularly in males.

Area of Science:

  • Immunogenetics
  • Hepatology
  • Viral Hepatitis Research

Background:

  • Hepatitis B virus (HBV) infection affects 400 million globally, with 10-15% of carriers developing severe liver disease.
  • Genetic factors, including human leukocyte antigen (HLA) variants, influence HBV infection chronicity.
  • Previous genome-wide association studies identified HLA variants rs3128917 and rs9380343 associated with persistent HBV.

Purpose of the Study:

  • To investigate the association between specific HLA gene variants and the chronicity of HBV infection.
  • To determine if HLA rs3128917 and rs9380343 polymorphisms influence the risk of persistent HBV infection.

Main Methods:

  • A case-control study was conducted involving 238 chronic HBV patients and 238 individuals with spontaneous HBV clearance.
  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was used to analyze HLA variants.

Main Results:

  • The rs9380343 polymorphism (both allele and genotype) showed a significant association with persistent HBV infection (p=0.038 and p=0.029, respectively).
  • The rs3128917 polymorphism did not show a significant association with persistent HBV infection.
  • rs9380343 polymorphism was also linked to an increased risk of HBV infection in males (p<0.05).

Conclusions:

  • The HLA rs9380343 polymorphism is identified as a genetic risk factor for the chronicity of HBV infection.
  • This study provides the first evidence linking HLA rs9380343 to persistent HBV infection.
  • Further validation with larger sample sizes and diverse populations is recommended to confirm these findings.
Abstract

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