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Updated: Jan 22, 2026
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The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress
Published on: July 4, 2013
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Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy
Avigeet Gupta1, Sina Koochakzadeh1, David M Neskey1
1Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, U.S.A.
The Laryngoscope
|July 11, 2019
Summary
Salivary gland carcinosarcomas are rare, aggressive tumors. Prompt surgery and radiation are recommended due to poor prognosis, with distant metastasis increasing mortality.
Area of Science:
- Oncology
- Head and Neck Surgery
- Pathology
Background:
- Carcinosarcomas are rare malignant tumors with mixed histology affecting salivary glands.
- Limited evidence exists regarding optimal management strategies for this aggressive malignancy.
Purpose of the Study:
- To determine the incidence and prognostic factors of salivary gland carcinosarcomas.
- To conduct a survival analysis for this rare and aggressive tumor type.
Main Methods:
- Retrospective review of the Surveillance, Epidemiology, and End Results (SEER) database.
- Analysis of 66 major salivary carcinosarcoma cases diagnosed between 1973 and 2015.
Main Results:
- The incidence of salivary carcinosarcoma is 0.02 per million, with increasing absolute cases recently.
- The parotid gland is the most common site; 5-year overall survival is 37% and disease-specific survival is 62%.
- Surgery (95.5%) and radiotherapy (75.8%) were common; chemotherapy was rare (18.2%). Distant metastasis significantly increased mortality, while total parotidectomy decreased it.
Conclusions:
- Salivary gland carcinosarcomas are rare, highly aggressive tumors with a poor prognosis.
- Prompt surgical management, including total parotidectomy when indicated, and postoperative radiation are recommended.
- Further research into prognostic factors and treatment optimization is warranted.
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