Related Experiment Video
Updated: Jan 22, 2026

Alphavirus Transducing System: Tools for Visualizing Infection in Mosquito Vectors
Published on: November 24, 2010
Evolution-Driven Attenuation of Alphaviruses Highlights Key Glycoprotein Determinants Regulating Viral Infectivity
Maria G Noval1, Bruno A Rodriguez-Rodriguez1, Margarita V Rangel1
1Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA.
Abstract:
Understanding the fundamental mechanisms of arbovirus transmission and pathogenesis is essential to develop strategies for treatment and prevention. We previously took an in vivo evolution-based approach and identified the chikungunya virus E1 glycoprotein residue 80 to play a critical role in viral transmission and pathogenesis. In this study, we address the genetic conservation and function of position 80 and demonstrate that this residue is a key determinant in alphavirus infectivity and dissemination through modulation of viral fusion and cholesterol dependence. In addition, in studying the evolution of position 80, we identified a network of glycoprotein residues, including epidemic determinants, that regulate virus dissemination and infectivity. These studies underscore the importance of taking evolution-based approaches to not only identify key viral determinants driving arbovirus transmission and pathogenesis but also to uncover fundamental aspects of arbovirus biology.
Related Concept Videos
Transcription Attenuation in Prokaryotes
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
The Evidence for Evolution
Key Elements for Plant Nutrition
Convergent Evolution
Viral Recombination
Key Techniques in Microbiology

