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Updated: Jan 22, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Tympanic Membrane Haematoma in a RivaroxabanTreated Patient: A Case Report
Inês Saldanha1, Ricardo Matos2, Tiago Órfão2
1Department of Otorhinolaryngology. Centro Hospitalar de S. João. Porto; Department of Surgery & Physiology/Otorhinolaryngology. Faculty of Medicine. University of Porto. Porto. Portugal.
Abstract:
New generation oral anticoagulants - rivaroxaban, apixaban and edoxaban - represent an important medical achievement. Their therapeutic effectiveness and ease of use make them essential in the management of thromboembolic conditions. However, as warfarin, they have known haemorrhagic risks. This paper reports the case of a 50-year-old female who presented with ear pain and spontaneous blood discharge in her right ear, after a two-week treatment with rivaroxaban. The physical examination revealed a spontaneous tympanic haematoma in the inferior quadrants, adjacent to the umbus. She denied any manipulation of the ear canal. Our goal is to alert for a presumable side effect of this drug in clinical practise.
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