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Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation
Published on: May 18, 2020
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In vitro disease models 4.0 via automation and high-throughput processing.
Sebastian Eggert1, Dietmar W Hutmacher1,2
1Centre in Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, 4059, Kelvin Grove, Australia.
Biofabrication
|July 12, 2019
Summary
Advancing 3D in vitro disease models requires automation. High-throughput methods will accelerate development and characterization, improving reproducibility and validation for research applications.
Area of Science:
- Biomedical Engineering
- Cell Biology
- Drug Discovery
Background:
- Physiologically relevant 3D in vitro disease models show promise.
- Current manufacturing and characterization are manual, slow, and error-prone.
- Low adoption, reproducibility, and validation hinder research progress.
Purpose of the Study:
- To advocate for automation and high-throughput methodologies in 3D in vitro disease model development.
- To highlight the need for innovative engineering solutions.
- To accelerate scientific rigor and applied research potential.
Main Methods:
- This perspective article discusses the limitations of current workflows.
- It proposes automation and high-throughput approaches as solutions.
- It emphasizes the role of engineering concepts.
Main Results:
- Automation and high-throughput methods are essential catalysts for progress.
- Innovative engineering can overcome current limitations.
- These advancements will enhance scientific rigor and applied research.
Conclusions:
- Automation and high-throughput methodologies are critical for the future of 3D in vitro disease models.
- Engineering innovation is key to improving efficiency, reproducibility, and validation.
- Accelerated development will benefit both fundamental and applied research.
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