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Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers
Kasper Katisko1, Antti Cajanus1, Titta Korhonen1
1Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Frontiers in Neuroscience
|July 12, 2019
Summary
Diagnosing behavioral variant of frontotemporal dementia (bvFTD) early is difficult due to psychiatric symptoms and memory issues. This review explores clinical signs and biomarkers for improved early bvFTD detection.
Area of Science:
- Neurology
- Neuroscience
- Psychiatry
Background:
- Early diagnosis of behavioral variant of frontotemporal dementia (bvFTD) remains challenging.
- bvFTD often presents with psychiatric symptoms, complicating diagnosis.
- Episodic memory impairment, a common feature, is an exclusion criterion for bvFTD.
Purpose of the Study:
- To evaluate core clinical features of early bvFTD.
- To summarize potential imaging and fluid biomarkers for bvFTD diagnostics.
Main Methods:
- Mini-review of existing literature.
- Evaluation of clinical presentations.
- Summary of diagnostic biomarker studies.
Main Results:
- bvFTD diagnosis is hindered by overlapping psychiatric symptoms and memory deficits.
- Current single biomarkers lack sufficient sensitivity and specificity for early bvFTD detection.
- Combinations of biomarkers show promise for improved diagnostic accuracy.
Conclusions:
- Accurate early diagnosis of bvFTD requires careful consideration of clinical features.
- Further research into combined imaging and fluid biomarkers is crucial for improving early bvFTD detection and management.
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