[Efficacy of ofloxacin against Neisseria gonorrhoeae]

Two beta-lactamase producing Neisseria gonorrhoeae strains with differing susceptibility to ofloxacin according to the minimum inhibitory concentration were exposed to the serum level time course of this chemotherapeutic agent in vitro. Within one hour, the bacterial density was markedly reduced, after another hour gonococci could not be subcultured anymore. In a comparative experimental setting the new cephalosporins have not led to total gonococcal eradication although they are also most efficient in gonorrhea. Therefore, quinolones such as ofloxacin should be also considered when it comes to gonorrhea treatment.