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In-vitro activity of cefpirome compared with that of other agents
1Medical University of S.C., Department of Medicine, Charleston 29425.
Abstract:
The in-vitro activity of cefpirome, cefotaxime, ticarcillin, piperacillin, and three aminoglycosides was compared by the broth dilution method against 248 consecutive clinical isolates of Pseudomonas aeruginosa and 35 aminoglycoside-resistant isolates of the Enterobacteriaceae. Cefpirome was more active against Ps. aeruginosa than cefotaxime and gentamicin, and as active as piperacillin, ticarcillin, tobramycin and amikacin. Ps. aeruginosa isolates resistant to a given aminoglycoside were significantly more resistant to cefpirome than isolates susceptible to that aminoglycoside. Other beta-lactam antibiotics were also less active against aminoglycoside-resistant strains of Ps. aeruginosa. Cefpirome was more potent than cefotaxime and the penicillins against aminoglycoside-resistant Enterobacteriaceae.