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Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study
Florencia Carbone1, Karen Van den Houte1, Egbert Clevers1
1Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium.
The American Journal of Gastroenterology
|July 12, 2019
Summary
Prucalopride significantly improved gastroparesis symptoms and quality of life in a clinical trial. This selective 5-hydroxytryptamine 4 receptor agonist also enhanced gastric emptying, offering a promising treatment for gastroparesis.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Prokinetics are the preferred treatment for gastroparesis, but evidence for their efficacy is limited.
- Prucalopride, a selective 5-hydroxytryptamine 4 receptor agonist, enhances gastric emptying and is used for constipation.
Purpose of the Study:
- To evaluate the efficacy of prucalopride in improving gastric emptying rate and symptoms in patients with gastroparesis.
Main Methods:
- A double-blind, randomized, placebo-controlled crossover study involving 34 patients with gastroparesis.
- Patients received 4-week treatment periods of placebo or prucalopride (2 mg q.d.), separated by a 2-week washout.
- Outcomes included the Gastroparesis Cardinal Symptom Index, quality of life assessments, and gastric emptying rate via C-octanoic acid breath test.
Main Results:
- Prucalopride significantly improved total Gastroparesis Cardinal Symptom Index scores compared to placebo (P < 0.0001).
- Improvements were observed in fullness, nausea, vomiting, bloating, and quality of life domains.
- Gastric half emptying time was significantly enhanced by prucalopride (P = 0.005).
Conclusions:
- Four weeks of prucalopride treatment significantly improved symptoms and quality of life in patients with gastroparesis.
- Prucalopride demonstrated efficacy in enhancing gastric emptying in this patient cohort.
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