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Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
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Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer
Bee Ling Tan1, Mohd Esa Norhaizan2,3,4
1Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Molecules (Basel, Switzerland)
|July 13, 2019
Summary
Combining curcumin with chemotherapy shows promise for improving cancer treatment. This approach may enhance drug effectiveness and reduce side effects, offering a novel strategy against cancer.
Area of Science:
- Oncology
- Pharmacology
- Natural Products Chemistry
Background:
- Chemotherapy is a cornerstone of cancer treatment, but faces limitations including drug resistance, poor therapeutic selectivity, and significant side effects.
- Natural compounds, such as curcumin, offer potential synergistic effects when combined with conventional chemotherapy.
- Curcumin, a polyphenol from Curcuma longa, exhibits diverse pharmacological activities with a favorable toxicity profile.
Purpose of the Study:
- To review the molecular mechanisms underlying the anticancer activity of combined curcumin and chemotherapy.
- To discuss the potential of nanoformulations for combined curcumin and chemotherapy delivery.
- To provide a comprehensive understanding of the implications of this combined therapeutic approach.
Main Methods:
- Literature review of in vitro and in vivo studies.
- Analysis of molecular pathways involved in combined curcumin-chemotherapy action.
- Exploration of nanoformulation strategies for enhanced drug delivery.
Main Results:
- Curcumin can modulate various signaling pathways, potentially overcoming chemotherapy resistance.
- Combined therapies may lead to enhanced tumor cell apoptosis and reduced proliferation.
- Nanoformulations of curcumin and chemotherapeutics show improved bioavailability and efficacy.
Conclusions:
- Combined curcumin and chemotherapy presents a promising strategy to enhance cancer treatment efficacy.
- Understanding the molecular mechanisms is crucial for optimizing this therapeutic approach.
- Further research into nanoformulated combined therapies could lead to improved clinical outcomes in cancer patients.
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