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Updated: Jan 22, 2026

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
Published on: February 24, 2021
Haemostasis and analgesia with autologous platelet-rich plasma in tonsillectomy
M N Chettri1, S K Jayagandhi2, Y Konyak3
1Department of ENT, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok, India.
Objective:
A single-centre, single-blinded prospective experimental study was conducted to determine the effectiveness of autologous platelet-rich plasma applied to the tonsillar bed post-operatively in reducing post-operative pain and haemorrhage.
Methods:
Platelet-rich plasma, prepared prior to surgery, was applied with calcium gluconate to one randomly chosen tonsillar fossa. Pain and haemorrhage were analysed, using a visual analogue scale and a pre-defined grading scale respectively, four times on the day of surgery at 2-hourly intervals, and thrice on the following day.
Results:
The pain score and haemorrhage grade on the test side were lower than on the control side. These findings were statistically significant.
Conclusion:
This pilot study, conducted in India, revealed valid positive results for a promising new technology. The manual preparation of platelet-rich plasma could be automated in the future to allow a larger sample size.
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