Related Experiment Video
Updated: Jan 22, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.6K
Eμ-TCL1xMyc: A Novel Mouse Model for Concurrent CLL and B-Cell Lymphoma
Fabienne Lucas1, Kerry A Rogers1, Bonnie K Harrington1,2
1Division of Hematology, The Ohio State University, Columbus, Ohio.
Summary
A novel mouse model uniformly develops aggressive B-cell lymphoma and chronic lymphocytic leukemia (CLL), offering a new platform for testing therapies against these aggressive lymphoid malignancies.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Aberrant Myc expression drives aggressive lymphoma pathogenesis, often leading to treatment resistance and poor outcomes.
- Aggressive lymphomas can co-occur with chronic lymphocytic leukemia (CLL), necessitating models to study combined therapeutic strategies.
Purpose of the Study:
- To develop a mouse model for studying therapeutic strategies in aggressive lymphoma within the context of CLL.
- To investigate the clinical and biological phenotype of concurrent B-cell-restricted oncogene expression.
Main Methods:
- Crossed Eμ-TCL1 and Eμ-Myc mouse models to create a double-transgenic Eμ-TCL1xMyc mouse.
- Characterized the resulting lymphoid malignancy clinically and biologically.
- Assessed therapeutic responses to ibrutinib and exportin-1 (XPO1) inhibition.
Main Results:
- Eμ-TCL1xMyc mice uniformly developed aggressive lymphoid disease with concurrent CLL and B-cell lymphoma, significantly reducing lifespan.
- Adoptive transfer of Eμ-TCL1xMyc cells into wild-type mice recapitulated the disease.
- Neither Eμ-TCL1xMyc mice nor those with transferred disease responded to ibrutinib.
- Selective inhibition of XPO1 demonstrated effective and durable disease control.
Conclusions:
- The Eμ-TCL1xMyc mouse model uniformly develops aggressive B-cell lymphoma and CLL.
- This model serves as a valuable preclinical tool for evaluating experimental drugs for aggressive B-cell lymphoma, particularly in the context of CLL.
- XPO1 inhibition shows promise for treating these aggressive lymphoid malignancies.
Related Concept Videos
02:43Mouse Models of Cancer Study
6.4K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.4K
02:00Molecular Models
43.6K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.6K
02:18The Bohr Model
80.4K
Following the work of Ernest Rutherford and his colleagues in the early twentieth century, the picture of atoms consisting of tiny dense nuclei surrounded by lighter and even tinier electrons continually moving about the nucleus was well established. This picture was called the planetary model since it pictured the atom as a miniature “solar system” with the electrons orbiting the nucleus like planets orbiting the sun. The simplest atom is hydrogen, consisting of a single proton as the...
80.4K
01:34The Fluid Mosaic Model
177.4K
The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
177.4K
02:16Stereotype Content Model
15.4K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.4K
01:09Clearance Models: Physiological Models
296
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
296