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Central sleep apnea: misunderstood and mistreated!
1Department of Population Health Sciences, University of Wisconsin - Madison, WARF Building, 7th Floor, 614 Walnut Street, Madison, WI 53726, USA.
F1000Research
|July 13, 2019
Summary
Central sleep apnea, common in heart failure and high-altitude dwellers, stems from heightened respiratory control sensitivity. Treatments may shift from positive airway pressure to neurochemical control modification.
Area of Science:
- Respirology
- Neurology
- Cardiology
Background:
- Central sleep apnea (CSA) frequently affects patients with heart failure, individuals at high altitudes, and chronic opiate users.
- CSA can also manifest initially as part of mixed sleep apneas, combining central and obstructive events.
Purpose of the Study:
- To review the underlying causes of cyclical central apneas.
- To explore alternative treatments for CSA focusing on neurochemical control.
Main Methods:
- Review of existing literature on respiratory control mechanisms.
- Analysis of neurochemical pathways involved in sleep apnea.
Main Results:
- Repetitive central apneas are primarily driven by enhanced sensitivities within the respiratory control system.
- Neurochemical modulation presents a potential therapeutic avenue for CSA.
Conclusions:
- Understanding the enhanced respiratory control sensitivity is key to addressing CSA.
- Targeting neurochemical control offers a promising alternative to positive airway pressure for CSA treatment.
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