Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long-Term...

Area of Science:

• Oral and Maxillofacial Surgery
• Pediatric Dentistry
• Endocrinology

Background:

• Central giant cell granuloma (CGCG) is a benign bone lesion in the head and neck.
• Maxillary CGCG can cause significant expansion due to bone structure.
• Surgical excision is standard but can be disfiguring, necessitating alternative treatments.

Observation:

• A 12-year-old female presented with CGCG of the left maxilla.
• The lesion exhibited aggressive and locally destructive potential.
• Maxillary location posed challenges for conservative management.

Findings:

• Treatment involved 40 doses of intralesional triamcinolone acetonide.
• Combined therapy included alendronate sodium and calcium carbonate.
• 12-year follow-up showed sustained clinical and imaging improvement.

Implications:

• Intralesional corticosteroid injections offer a viable alternative to surgery for maxillary CGCG.
• Combination therapy may enhance bone healing and lesion stabilization.
• This approach provides a less disfiguring option for pediatric patients with aggressive CGCG.