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Ultrastructural evidence of the evolutional process in malakoplakia
Yeon Seung Jung1, Dong Yong Chung2, Eun Jin Kim2
1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Histology and Histopathology
|July 13, 2019
Summary
Malakoplakia, a condition linked to incomplete digestion of Escherichia coli, involves unique phagolysosome processes. This study reveals the sequential stages of Michaelis-Gutmann body formation, offering new insights into malakoplakia pathogenesis.
Area of Science:
- Cell Biology
- Pathology
- Microbiology
Background:
- Malakoplakia is characterized by recurrent urinary tract infections and mass-forming lesions.
- It arises from the incomplete digestion of Escherichia coli by lysosomes.
- These events can mimic tumor formation.
Purpose of the Study:
- To elucidate the phagolysosome process in malakoplakia development.
- To detail the formation of Michaelis-Gutmann (MG) bodies using ultrastructural analysis.
Main Methods:
- Observation of MG body formation in three malakoplakia patients.
- Comparison with xanthogranulomatous pyelonephritis cases.
- Utilized transmission and scanning electron microscopy (SEM).
Main Results:
- Identified pre-phagosomal, phagosomal, and post-phagosomal stages of MG body development.
- Demonstrated lysosomal aggregation and incomplete digestion of pathogens as key to the pre-phagosomal stage.
- Observed phagosome formation via fusion of pathogens and lysosomes.
Conclusions:
- First-time recognition of E. coli within phagosomes or damaged by lysosomal attack.
- SEM provided novel insights into phagolysosome formation in human tissue.
- Detailed the sequential events leading to malakoplakia formation.
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