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Heritability estimation of dichotomous phenotypes using a liability threshold model on ascertained family-based
Wonji Kim1,2, Soo Heon Kwak3, Sungho Won2,4,5
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Genetic Epidemiology
|July 13, 2019
Summary
We developed a new statistical method to estimate heritability for dichotomous phenotypes, which are complex to analyze. This approach improves accuracy for family-based genetic studies.
Area of Science:
- Genetics
- Biostatistics
Background:
- Estimating heritability for dichotomous phenotypes is challenging.
- Existing methods are computationally complex and infrequently used.
Purpose of the Study:
- To develop a novel statistical method for heritability estimation in dichotomous phenotypes.
- To apply the method to ascertained family-based samples.
Main Methods:
- Utilized a liability threshold model assuming normally distributed latent variables.
- Applied the method to simulated data and Korean type-2 diabetes family samples.
Main Results:
- The developed method accurately estimates heritability for dichotomous traits.
- Compared the accuracy of the new method against established approaches.
Conclusions:
- The proposed liability threshold model offers a viable approach for heritability estimation in dichotomous phenotypes.
- This method enhances the analysis of genetic contributions in family-based studies.
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