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Updated: Jan 22, 2026
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Ruthenium-Catalyzed Synthesis of N-Methylated Amides using Methanol
Bhaskar Paul1, Dibyajyoti Panja1, Sabuj Kundu1
1Department of Chemistry , Indian Institute of Technology , Kanpur , Uttar Pradesh 208016 , India.
Abstract:
An efficient synthesis of N-methylated amides using methanol in the presence of a ruthenium(II) catalyst is realized. Notably, applying this process, tandem C-methylation and N-methylation were achieved to synthesize α-methyl N-methylated amides. In addition, several kinetic studies and control experiments with the plausible intermediates were performed to understand this novel protocol. Furthermore, detailed computational studies were carried out to understand the mechanism of this transformation.
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