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Abnormal factor VIII in chronic renal failure.

M A Howard, J A Whitworth, L E Hendrix

    The Medical Journal of Australia
    |March 10, 1979
    PubMed
    Summary
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    Patients with chronic renal failure (CRF) showed varied levels of factor VIII (FVIII) functions, with no correlation between them. These FVIII changes in CRF patients suggest caution when interpreting FVIII status in other conditions like liver disease.

    Area of Science:

    • Hematology
    • Nephrology
    • Clinical Chemistry

    Background:

    • Factor VIII (FVIII) is crucial for hemostasis.
    • Chronic renal failure (CRF) can impact coagulation factors.
    • Understanding FVIII alterations in CRF is important for patient management.

    Purpose of the Study:

    • To investigate the levels and characteristics of Factor VIII procoagulant activity (VIII-C), related antigen (VIII-AG), and von Willebrand factor (VIII-vWf) in patients with CRF.
    • To compare FVIII parameters between CRF patients, non-CRF medical patients, and healthy controls.
    • To assess the electrophoretic mobility (EM) of FVIII in CRF patients.

    Main Methods:

    • Measurement of VIII-C, VIII-AG, and VIII-vWf in 38 CRF patients, 19 medical controls, and 17 healthy subjects.

    Related Experiment Videos

  • Analysis of correlations between the three FVIII functions within the CRF group.
  • Assessment of increased electrophoretic mobility (EM) in CRF patients.

    • Main Results:

    • Wide variations in FVIII functions were observed in CRF patients.
    • No correlation was found between the three individual FVIII activities in renal disease.
    • FVIII functions were elevated in both CRF and medical patient groups compared to normal subjects.
    • Increased electrophoretic mobility (EM) was detected in 58% of CRF patients versus 37% of controls.

    Conclusions:

    • FVIII levels and characteristics are significantly altered in patients with chronic renal failure.
    • The lack of correlation between FVIII functions in CRF suggests complex regulatory changes.
    • Findings indicate that caution is needed when interpreting FVIII status in CRF patients, especially when considering co-existing conditions like liver disease.