Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synaptic Signaling01:12

Synaptic Signaling

79.2K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
79.2K
Balancing Redox Equations02:58

Balancing Redox Equations

61.7K
Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
61.7K
Oscillations In An LC Circuit01:30

Oscillations In An LC Circuit

3.0K
An idealized LC circuit of zero resistance can oscillate without any source of emf by shifting the energy stored in the circuit between the electric and magnetic fields. In such an LC circuit, if the capacitor contains a charge q before the switch is closed, then all the energy of the circuit is initially stored in the electric field of the capacitor. This energy is given by
3.0K
Forced Oscillations01:06

Forced Oscillations

7.7K
When an oscillator is forced with a periodic driving force, the motion may seem chaotic. The motions of such oscillators are known as transients. After the transients die out, the oscillator reaches a steady state, where the motion is periodic, and the displacement is determined.
7.7K
Energy Balance01:19

Energy Balance

1.2K
The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...
1.2K
Equilibrium and Balance01:15

Equilibrium and Balance

6.4K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Predictive coding of reward in the hippocampus.

Nature·2026
Same author

Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex.

bioRxiv : the preprint server for biology·2026
Same author

Fast Spiking Interneurons Autonomously Generate Fast Gamma Oscillations in the Medial Entorhinal Cortex with Excitation Strength Tuning ING-PING Transitions.

eNeuro·2026
Same author

Predictive coding of reward in the hippocampus.

Nature·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Correction: Nonnegative matrix factorization for analyzing state dependent neuronal network dynamics in calcium recordings.

Scientific reports·2025

Related Experiment Video

Updated: Jan 22, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

21.1K

Balanced synaptic currents underlie low-frequency oscillations in the subiculum.

Feliks Royzen1,2, Sylvain Williams3, Fernando R Fernandez4

  • 1Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, Utah.

Hippocampus
|July 14, 2019
PubMed
Summary

Hippocampal oscillations involve balanced excitatory and inhibitory synaptic currents. This balance drives synchronized neuronal firing during theta range network oscillations in the hippocampus.

Keywords:
E/I balanceelectrophysiologynetwork oscillationssubiculumwhole hippocampal preparation

More Related Videos

Recording Gamma Band Oscillations in Pedunculopontine Nucleus Neurons
09:04

Recording Gamma Band Oscillations in Pedunculopontine Nucleus Neurons

Published on: September 14, 2016

9.0K
Focal Macropatch Recordings of Synaptic Currents from the Drosophila Larval Neuromuscular Junction
07:01

Focal Macropatch Recordings of Synaptic Currents from the Drosophila Larval Neuromuscular Junction

Published on: September 25, 2017

6.4K

Related Experiment Videos

Last Updated: Jan 22, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

21.1K
Recording Gamma Band Oscillations in Pedunculopontine Nucleus Neurons
09:04

Recording Gamma Band Oscillations in Pedunculopontine Nucleus Neurons

Published on: September 14, 2016

9.0K
Focal Macropatch Recordings of Synaptic Currents from the Drosophila Larval Neuromuscular Junction
07:01

Focal Macropatch Recordings of Synaptic Currents from the Drosophila Larval Neuromuscular Junction

Published on: September 25, 2017

6.4K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cellular Neuroscience

Background:

  • Hippocampal oscillations are crucial for memory and cognition.
  • Mechanisms generating these oscillations, particularly synaptic conductances, remain incompletely understood.
  • Direct measurements of synaptic and intrinsic properties during oscillations are limited.

Purpose of the Study:

  • To investigate the interplay of excitatory and inhibitory synaptic conductances during hippocampal low-frequency oscillations.
  • To elucidate the role of intrinsic membrane properties in shaping neuronal responses to synaptic inputs.
  • To clarify the mechanisms driving pyramidal cell and interneuron spiking during network oscillations.

Main Methods:

  • Utilized an isolated whole hippocampal preparation exhibiting autonomous low-frequency oscillations.
  • Employed 2-photon microscopy and genetically encoded fluorophores for cellular visualization.
  • Performed on-cell and whole-cell patch-clamp recordings from hippocampal pyramidal cells and interneurons.

Main Results:

  • Pyramidal cell and interneuron spiking were similarly phase-locked to local field potential oscillations.
  • Pyramidal cell spiking resulted from balanced increases in excitatory and inhibitory synaptic currents.
  • Interneuron spiking was predominantly driven by excitatory synaptic currents.

Conclusions:

  • Balanced synaptic inputs contribute to highly phase-locked spiking in hippocampal networks during oscillations.
  • The findings provide insights into network dynamics underlying theta oscillations.
  • This study contributes to understanding the fundamental mechanisms of hippocampal network function.