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The simian crease: Relationship to various genetic disorders
Lauren Wahl1, Graham Dupont1, R Shane Tubbs1,2
1Seattle Science Foundation, Seattle, Washington.
The simian crease, a single palmar crease, is rare but clinically significant for diagnosing congenital disorders. This review details its history, embryology, genetics, and diagnostic importance for clinicians.
Area of Science:
- Anatomy
- Genetics
- Anthropology
Background:
- Palmar creases have long interested clinicians and anthropologists.
- The simian crease, resembling primate palmar creases, is recognized for its abnormal appearance and cytogenetic links.
Purpose of the Study:
- To review the history, embryology, genetics, and clinical significance of simian creases.
- To provide diagnostic knowledge for clinicians regarding congenital disorders associated with simian creases.
Main Methods:
- Literature review focusing on simian creases.
- Analysis of historical, embryological, genetic, and clinical data.
Main Results:
- Simian creases are rare but diagnostically valuable.
- Understanding their origins aids in identifying congenital conditions.
Conclusions:
- Simian creases are important markers for congenital disorders.
- This review offers valuable insights for clinical diagnosis.
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