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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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tRNA Activation

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Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
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Decoding Natural Behavior from Neuroethological Embedding
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Decoding Natural Behavior from Neuroethological Embedding

Published on: October 3, 2025

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Decoding the PTM-switchboard of Notch.

Daniel Antfolk1, Christian Antila1, Kati Kemppainen1

  • 1Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Turku, Finland.

Biochimica Et Biophysica Acta. Molecular Cell Research
|July 14, 2019
PubMed
Summary
This summary is machine-generated.

Post-translational modifications (PTMs) dynamically regulate the Notch pathway

Keywords:
GlycosylationNotchPTMPhosphorylationPost-translational modifications

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Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • The Notch pathway is crucial for development and exhibits pleiotropic effects.
  • Post-translational modifications (PTMs) are emerging as key regulators of Notch signaling activity.
  • Understanding PTMs is vital for deciphering diverse Notch phenotypes.

Purpose of the Study:

  • To review known PTMs of the Notch pathway.
  • To summarize their functions in various biological contexts.
  • To explore implications in physiology and disease.

Main Methods:

  • Literature review of PTMs on the Notch signaling pathway.
  • Analysis of PTM functions and crosstalk mechanisms.
  • Overview of current PTM research methodologies.

Main Results:

  • PTMs like glycosylation and phosphorylation modulate Notch activity and stability.
  • Specific modification sites correlate with distinct Notch outputs.
  • PTMs can cooperate or compete, leading to varied signaling outcomes.

Conclusions:

  • PTMs are critical for fine-tuning Notch signaling.
  • Further research into PTM crosstalk is needed for a comprehensive understanding.
  • PTM-targeted therapeutics hold future promise for Notch-related diseases.