Related Experiment Video

Updated: Jan 22, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.4K

The association between iron deficiency anemia and febrile seizure

Parviz Karimi1, Koroush Sayehmiri2, Milad Azami3

  • 1Department of Pediatric Diseases, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

International Journal of Adolescent Medicine and Health
|July 14, 2019
PubMed

Insights

Iron deficiency anemia (IDA) may protect against febrile seizures (FS) in children. IDA was more prevalent in children with afebrile seizures, suggesting a potential protective role against FS.

Area of Science:

  • Pediatrics
  • Neurology
  • Hematology

Background:

  • Contradictory findings exist regarding the association between iron deficiency anemia (IDA) and febrile seizures (FS).
  • Understanding this relationship is crucial for pediatric health management.

Purpose of the Study:

  • To investigate the effect of IDA on the occurrence of FS in children.
  • To clarify the association between IDA and different seizure types in pediatric patients.

Main Methods:

  • A case-control study involving 52 children with FS, 18 with afebrile seizures, and 51 with fever without seizures (ages 6 months to 5 years).
  • Blood parameters including hemoglobin, hematocrit, ferritin, and red blood cell indices were measured.
  • Statistical analysis was performed to compare IDA prevalence and seizure risk.

Main Results:

  • IDA prevalence was 34.6% in the FS group, 66.7% in the afebrile seizure group, and 41.2% in the fever without seizure group; no statistically significant difference was found between groups.
  • Children with FS had higher hemoglobin, hematocrit, and RBC levels, and lower MCV, MCH, and MCHC levels compared to controls.
  • The odds ratio for FS compared to febrile group was 0.756 (p=0.493), and compared to seizure group was 0.265 (p=0.022).

Conclusions:

  • IDA may exert a protective effect against the onset of febrile seizures in children.
  • IDA appears to be more common in children experiencing afebrile seizures.
  • Further extensive research is recommended to confirm these findings.
Abstract

Keywords:
IDAadolescentnurse

More Related Videos

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.5K
A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

5.6K

Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.4K
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.1K
Associative Learning01:27

Associative Learning

Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.2K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.4K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.4K