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Published on: June 14, 2018
Diagnostic performance of ultrasound without any colon preparation for detecting colorectal polyps in pediatric
Takahiro Hosokawa1, Mayumi Hosokawa2, Yutaka Tanami3
1Department of Radiology, Saitama Children's Medical Center, 1-2 Shintoshin Chuo-ku Saitama, Saitama, 330-8777, Japan. snowglobe@infoseek.jp.
Insights
Ultrasound shows 89% accuracy for detecting colorectal polyps in children, with smaller or rectal polyps causing false negatives. This non-invasive method aids in pediatric polyp diagnosis.
Area of Science:
- Pediatric Gastroenterology
- Diagnostic Imaging
- Colorectal Health
Background:
- Limited data exists on ultrasound's effectiveness for detecting colorectal polyps in pediatric patients.
- Accurate non-invasive diagnostic tools are needed for pediatric colorectal conditions.
Purpose of the Study:
- To assess the diagnostic accuracy of ultrasound for detecting colorectal polyps in children without colon preparation.
- To identify factors contributing to false-negative ultrasound results in pediatric polyp detection.
Main Methods:
- A cohort of 74 children with symptoms like rectal bleeding or abdominal pain underwent both ultrasound and colonoscopy.
- Ultrasound's diagnostic performance was evaluated against colonoscopy, the reference standard.
- Statistical analyses included Fisher exact and Student's t-tests.
Main Results:
- Ultrasound demonstrated an overall accuracy of 89% (95% CI, 80-95%) for detecting colorectal polyps.
- Sensitivity was 47% and specificity was 100%.
- False-negative results were associated with smaller polyp volumes and polyps located in the rectum.
Conclusions:
- Ultrasound is an accurate tool for detecting colorectal polyps in pediatric patients, achieving 89% accuracy.
- Smaller polyps and those in the rectum are more likely to be missed by ultrasound, leading to false negatives.
Background:
There are limited data on the sensitivity, specificity and accuracy of ultrasound for detecting colorectal polyps in children and young adults.
Objective:
To evaluate the diagnostic accuracy of ultrasound, without any colon preparation, for detecting colorectal polyps in pediatric patients and to determine the causes of false-negative results.
Materials And Methods:
We included 74 children with clinical signs like rectal bleeding, abdominal pain or diarrhea who underwent both ultrasound and colonoscopy. We evaluated the diagnostic performance of ultrasound for detecting colorectal polyps before colonoscopy, which served as the reference standard. We used Fisher exact and Student's t-tests for statistical analyses.
Results:
Fifteen pediatric patients were diagnosed with colorectal polyps in the transverse (n=3), descending (n=1) and sigmoid (n=6) colon, and rectum (n=5) by colonoscopy. The sensitivity, specificity and accuracy of ultrasound to detect colorectal polyps were 47% (7/15, 95% confidence interval [CI] 21-73%), 100% (59/59, 95% CI 94-100%) and 89% (66/74, 95% CI 80-95%), respectively. The volume (mean ± standard deviation) of polyps not detected by ultrasound was significantly smaller than that detected (270±380 mm3 vs. 4,600±3,900 mm3, P=0.0124). We observed a significant difference in the location between the polyps detected and not detected by ultrasound (rectal/non-rectal=0/7 vs. 5/3, P=0.0256). No significant age or gender difference was observed.
Conclusion:
The accuracy for detecting colorectal polyps by ultrasound was 89% (95% CI, 80-95%) in our cohort. Polyps found in the rectum and relatively smaller polyps accounted for several false-negative cases.
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