Related Experiment Video
Updated: Jan 22, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Asymmetric synthesis of hetero-1,2,3,4,5-pentasubstituted ferrocenes
William Erb1, Thierry Roisnel1
1Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes), UMR 6226, F-35000 Rennes, France. william.erb@univ-rennes1.fr.
Abstract:
The first synthesis of enantioenriched ferrocenes bearing five different substituents on the same cyclopentadienyl ring is described through an unprecedented asymmetric halogen 'dance' reaction. This work not only extends the chemistry of fluoroferrocene derivatives and constitutes the very first entry into the world of enantioenriched hetero-pentasubstituted ferrocenes, it also lays the foundation for research in other metallocene families.
Related Concept Videos
Rotation of Asymmetric Top
The relationship between the angular momentum of any rigid body and its angular velocity, both of which are vectors, involves the moment of inertia. The moment of inertia is a scalar quantity only for spherically symmetric...
Asymmetric Lipid Bilayer
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
Synthesis and Decomposition Reactions
Lagging Strand Synthesis
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...

