Multifunctional Hydrophobized Microparticles for Accelerated Wound Healing after Endoscopic Submucosal Dissection

Area of Science:

• Biomaterials Science
• Gastroenterology
• Regenerative Medicine

Background:

• Endoscopic submucosal dissection (ESD) is a minimally invasive treatment for early gastrointestinal cancer.
• Scar contracture and cicatricial stricture are common complications following ESD, with no current reliable preventative treatments.
• Effective wound healing and tissue regeneration strategies are crucial for improving patient outcomes after ESD.

Purpose of the Study:

• To develop and evaluate a multifunctional colloidal wound dressing for promoting tissue regeneration after ESD.
• To investigate the wound healing capabilities of a sprayable, microparticle-based dressing.
• To assess the dressing's potential in preventing fibrosis and accelerating healing in a relevant animal model.

Main Methods:

• Fabrication of a sprayable colloidal wound dressing using hydrophobized microparticles.
• Evaluation of the dressing's inherent properties: tissue adhesiveness, blood coagulation, re-epithelialization, angiogenesis, and controlled inflammation.
• In vivo feasibility study using swine gastric endoscopic submucosal dissection (ESD) models.

Main Results:

• The colloidal wound dressing demonstrated multifunctionality essential for wound healing.
• The sprayable dressing effectively suppressed fibrosis in swine gastric ESD models.
• Accelerated wound healing was observed in the treated swine gastric ESD models.

Conclusions:

• The developed multifunctional colloidal wound dressing shows significant therapeutic potential for promoting tissue regeneration post-ESD.
• This sprayable wound dressing offers a promising approach to prevent complications like stricture formation after gastrointestinal procedures.
• The technology has broad biomedical applications, including accelerated wound healing and treatment of inflammatory diseases.