Related Experiment Video
Updated: Jan 22, 2026

Synthesis of In37P20O2CR51 Clusters and Their Conversion to InP Quantum Dots
Published on: May 7, 2019
Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2
Ming-Hsien Chan1,2, Chen-Yu Lai3, Yung-Chieh Chan4
1Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.
Abstract:
Aim: Matrix metalloproteinase-2 (MMP2) plays an important role in extracellular matrix remodeling, that is, it increases significantly during cancer progression. In this regard, MMP2 monitoring is important. Experiment: A well-designed MMP2-sensitive polypeptide chain was used to link indium phosphide quantum dots (InP QDs) with upconversion nanoparticles (UCNPs) to form a nanocomposite that was utilized as biosensor. Results: We produced a biosensor that can be recognized by MMP2 and determined the presence or absence of MMP2 in cells by identifying difference in fluorescence wavelength. The InP QDs modified the arginylglycylaspartic acid molecules as targeting ligand based on chitosan. Conclusion: The MMP2-based biosensor, named UCNP-p@InP-cRGD, is sensitive and can be applied for biosensing probes.
Related Concept Videos
Quantum Numbers
The Quantum-Mechanical Model of an Atom
Conjugated Proteins
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Piaget's Stage 2 of Cognitive Development
The Sense of Self: Reflected Self-Appraisal and Social Comparison

