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siRNA - Small Interfering RNAs02:30

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
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Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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Use of Alu Element Containing Minigenes to Analyze Circular RNAs

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Circular RNAs in leukemia.

Zijuan Wu1,2,3, Handong Sun4, Jianyong Li1,2,3

  • 1Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.

Aging
|July 16, 2019
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are key non-coding RNAs with vital functions. This review explores their role in leukemia, highlighting their potential as diagnostic biomarkers and therapeutic targets.

Keywords:
aging diseasebiomarkercircRNAsleukemianon-coding RNAstherapy

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Related Experiment Videos

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Identification of Circular RNAs using RNA Sequencing
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Area of Science:

  • Genomics
  • Molecular Biology
  • Biochemistry

Background:

  • The human genome transcribes 70-90% of RNAs, but only 2% encode proteins, indicating significant roles for non-coding RNAs (ncRNAs).
  • Advancements in high-throughput sequencing have identified circular RNAs (circRNAs) involved in biological processes and diseases.
  • circRNAs are increasingly recognized for their potential in disease diagnosis and therapy.

Purpose of the Study:

  • To review the general information of circRNAs.
  • To focus on the association between dysregulated circRNAs and leukemia.
  • To highlight the clinical translational potential of circRNAs in leukemia.

Main Methods:

  • Literature review of studies on circRNAs and leukemia.
  • Analysis of current research on circRNA functions and mechanisms in leukemia.
  • Synthesis of information regarding circRNAs as biomarkers and therapeutic targets.

Main Results:

  • circRNAs are implicated in various biological processes and diseases, including leukemia.
  • Dysregulated circRNAs are associated with the occurrence and development of leukemia.
  • circRNAs show promise as diagnostic biomarkers and therapeutic targets for leukemia.

Conclusions:

  • A comprehensive understanding of circRNAs in leukemia is crucial for clinical translation.
  • circRNAs represent promising avenues for novel diagnostic, therapeutic, and drug screening strategies in leukemia.
  • Further research into circRNAs will advance the clinical application of non-coding RNA biology in leukemia treatment.