Related Experiment Video
Updated: Jan 22, 2026

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits
Published on: March 15, 2024
Bumetanide: A review of its neuroplasticity and behavioral effects after stroke
Dongxia Tao1, Fangxi Liu1, Xiaoyu Sun2
1Neurology, The First Hospital of China Medical University, Shenyang, China.
Abstract:
Stroke often leads to neuronal injury and neurological functional deficits. Whilst spontaneous neurogenesis and axon regeneration are induced by ischemic stroke, effective pharmacological treatments are also essential for the improvement of neuroplasticity and functional recovery after stroke. However, no pharmacological therapy has been demonstrated to be able to effectively improve the functional recovery after stroke. Bumetanide is a specific Na+-K+-Cl- co-transporter inhibitor which can maintain chloride homeostasis in neurons. Therefore, many studies have focused on this drug's effect in stroke recovery in recent years. Here, we first review the function of Na+-K+-Cl- co-transporter in neurons, then how bumetanide's role in reducing brain damage, promoting neuroplasticity, leading to functional recovery after stroke, is elucidated. Finally, we discuss current limitations of bumetanide's efficiency and their potential solutions. These results may provide new avenues for further exploring mechanisms of post-stroke functional recovery as well as promising therapeutic targets for functional disability rehabilitation after ischemic stroke.
Related Concept Videos
Neuroplasticity
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
What is Behavior?
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...

