Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychology as a Science01:13

Psychology as a Science

3.8K
Psychology, as a scientific discipline, aims to understand the mind and behavior through rigorous and systematic methods. The foundation of psychological research is evidence-based, relying heavily on the scientific method to derive and validate knowledge. This structured approach ensures that findings are reliable, valid, and applicable to broader contexts.
The scientific method in psychology involves six critical steps: making observations, formulating hypotheses, conducting tests, analyzing...
3.8K
Overview of Biostatistics in Health Sciences01:19

Overview of Biostatistics in Health Sciences

4.8K
Biostatistics involves the application of statistical techniques to scientific research in health-related fields, including biology and public health. These techniques are essential for designing studies, collecting data, and analyzing it to draw meaningful conclusions. Given the complexity of biological processes, particularly in studies involving human subjects, biostatistical methods are crucial for effectively organizing and interpreting data that might otherwise obscure underlying patterns...
4.8K
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

671
Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
671
Formulating and Validating Nursing Diagnosis II01:25

Formulating and Validating Nursing Diagnosis II

3.6K
Nursing diagnoses represent a problem validated by major defining characteristics. There are four categories of nursing diagnoses: problem-focused, risk, health promotion or wellness, and syndrome. The anatomy of a nursing diagnosis includes three components: problem statement or diagnostic label, defining characteristics, and related factors.
Risk nursing diagnoses represent clinical judgments of an individual, family, or community more vulnerable to developing the health problem than others...
3.6K
Moment of a Force: Scalar Formulation01:18

Moment of a Force: Scalar Formulation

3.3K
The moment of a force, also known as torque, measures the ability of the force to create rotational motion in a body about an axis. It is a vector quantity, meaning it has both magnitude and direction. This concept is used extensively in engineering, physics, and mechanics.
Consider a simple example of a flywheel being rotated about a point, O, by applying a force to it. In this case, the moment arm is the perpendicular distance between the point O and the line of action of the force. The...
3.3K
Resultant Moment: Scalar Formulation01:31

Resultant Moment: Scalar Formulation

2.3K
When multiple forces act on an object in two-dimensional space, the concept of the net moment can be used to understand the tendency of these forces to induce rotational motion about a fixed point. The scalar formulation of the resultant moment is a helpful tool in analyzing the equilibrium of structures subjected to multiple forces.
To determine the resultant moment, the moments caused by all the forces in a system in the x-y plane are considered. Positive moments are typically...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accelerated Storage for Shelf-Life Prediction of Lyophiles: Temperature Dependence of Degradation of Amorphous Small Molecular Weight Drugs and Proteins.

Journal of pharmaceutical sciences·2023
Same author

Strategies for Implementing New Drying & Packaging Technology for Sterile Injectable Drug Products.

Journal of pharmaceutical sciences·2021
Same author

Water Distribution and Clustering on the Lyophilized IgG1 Surface: Insight from Molecular Dynamics Simulations.

Molecular pharmaceutics·2020
Same author

Impact of Formulation and Suspension Properties on Redispersion of Aluminum-Adjuvanted Vaccines.

Journal of pharmaceutical sciences·2020
Same author

Bulk Dynamic Spray Freeze-Drying Part 2: Model-Based Parametric Study for Spray-Freezing Process Characterization.

Journal of pharmaceutical sciences·2019
Same author

Bulk Dynamic Spray Freeze-Drying Part 1: Modeling of Droplet Cooling and Phase Change.

Journal of pharmaceutical sciences·2019

Related Experiment Video

Updated: Jan 22, 2026

X-ray Powder Diffraction in Conservation Science: Towards Routine Crystal Structure Determination of Corrosion Products on Heritage Art Objects
09:16

X-ray Powder Diffraction in Conservation Science: Towards Routine Crystal Structure Determination of Corrosion Products on Heritage Art Objects

Published on: June 8, 2016

16.7K

Science and art of protein formulation development.

Wei Wang1, Satoshi Ohtake2

  • 1Biological Development, Bayer USA, LLC, 800 Dwight Way, Berkeley, CA 94710, United States.

International Journal of Pharmaceutics
|July 16, 2019
PubMed
Summary

Developing protein pharmaceuticals involves complex formulation. This review discusses formulation challenges, processes, and strategies for protein drug products to ensure successful commercialization.

Keywords:
AggregationFormulationProcessProteinStabilityStorage

More Related Videos

Examining Changes in HRV and Emotion Following Artmaking with Three Different Art Materials
06:24

Examining Changes in HRV and Emotion Following Artmaking with Three Different Art Materials

Published on: January 11, 2020

6.7K
Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
06:06

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles

Published on: March 9, 2019

5.8K

Related Experiment Videos

Last Updated: Jan 22, 2026

X-ray Powder Diffraction in Conservation Science: Towards Routine Crystal Structure Determination of Corrosion Products on Heritage Art Objects
09:16

X-ray Powder Diffraction in Conservation Science: Towards Routine Crystal Structure Determination of Corrosion Products on Heritage Art Objects

Published on: June 8, 2016

16.7K
Examining Changes in HRV and Emotion Following Artmaking with Three Different Art Materials
06:24

Examining Changes in HRV and Emotion Following Artmaking with Three Different Art Materials

Published on: January 11, 2020

6.7K
Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
06:06

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles

Published on: March 9, 2019

5.8K

Area of Science:

  • Biotechnology
  • Pharmaceutical Sciences
  • Drug Development

Background:

  • Protein pharmaceuticals represent a growing market segment with significant therapeutic value.
  • The commercialization of protein-based drugs is intricate, with formulation being a crucial determinant of product success.
  • Existing challenges in formulation development necessitate a comprehensive review of current practices.

Purpose of the Study:

  • To delineate the key challenges encountered during protein pharmaceutical formulation.
  • To elucidate the fundamental processes involved in formulation development for protein drugs.
  • To compare various strategic options and practical approaches in protein formulation development.

Main Methods:

  • Literature review of scientific publications and industry best practices.
  • Analysis of common formulation strategies for protein-based therapeutics.
  • Comparative assessment of different formulation development pathways.

Main Results:

  • Identification of critical challenges including stability, aggregation, and delivery of protein drugs.
  • Overview of essential formulation steps: excipient selection, process optimization, and stability testing.
  • Comparison of formulation approaches, highlighting trade-offs between different strategies.

Conclusions:

  • Addressing formulation challenges is paramount for the successful development of protein pharmaceuticals.
  • A systematic approach to formulation development, considering stability and efficacy, is essential.
  • Strategic planning and comparison of options can optimize the path to commercial protein drug products.