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Antiphospholipid antibodies--autoantibodies with a difference.
E N Harris1, R A Asherson, G R Hughes
1Lupus Research Laboratory, Rayne Institute, St. Thomas' Hospital, London, England.
Annual Review of Medicine
|January 1, 1988
Summary
Antiphospholipid antibodies are linked to blood clots and pregnancy loss. Early detection and treatments like aspirin, prednisone, or anticoagulants may improve outcomes for affected individuals.
Area of Science:
- Immunology
- Obstetrics & Gynecology
- Hematology
Background:
- Antiphospholipid antibodies (aPL) are a group of autoantibodies.
- Their presence is associated with clinical conditions such as thrombosis and pregnancy complications.
Purpose of the Study:
- To review the detection, associated clinical features, and management of antiphospholipid antibodies.
Main Methods:
- Review of diagnostic methods including anticardiolipin antibody tests, lupus anticoagulant test, and standard tests for syphilis.
- Analysis of clinical associations and suggested features.
- Evaluation of therapeutic strategies for pregnancy loss and thrombosis.
Main Results:
- aPL detection methods are varied.
- Associated conditions include venous/arterial thrombosis, fetal loss, thrombocytopenia, livedo reticularis, migraine, chorea, and heart valve lesions.
- Preliminary evidence suggests prednisone and aspirin may improve pregnancy outcomes in recurrent fetal loss.
Conclusions:
- Antiphospholipid antibodies are associated with significant clinical morbidity.
- Management strategies include anticoagulation for thrombosis and potential use of prednisone and aspirin during pregnancy for recurrent fetal loss.
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