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Deep vein thrombosis and pulmonary embolism: clinical presentation and pathophysiologic consequences
1Section of Vascular Surgery, Temple University Hospital, Philadelphia, PA 19140.
Cardiovascular and Interventional Radiology
|January 1, 1988
Summary
Thrombolytic therapy offers superior outcomes for deep vein thrombosis (DVT) and pulmonary embolism (PE) compared to traditional treatments. This approach significantly improves venous system clearing and long-term patient function.
Area of Science:
- Vascular Medicine
- Thrombotic Disorders
Background:
- Deep vein thrombosis (DVT) and pulmonary embolism (PE) present diagnostic challenges and can lead to lasting complications.
- Popliteal valvular insufficiency in DVT patients elevates the risk of postphlebitic syndrome.
Purpose of the Study:
- To evaluate the efficacy of thrombolytic therapy versus anticoagulation for DVT.
- To compare thrombolytic therapy with heparin for PE treatment, assessing acute and long-term outcomes.
Main Methods:
- Review of current data comparing thrombolytic therapy with anticoagulation for DVT.
- Analysis of studies investigating thrombolytic therapy versus heparin for PE.
Main Results:
- Thrombolytic therapy achieved significant or complete deep venous system clearing in nearly half of DVT patients.
- Lytic therapy demonstrated greater effectiveness than heparin in treating PE, improving both acute resolution and long-term function.
Conclusions:
- Thrombolytic therapy is more effective than anticoagulation for DVT, leading to better venous system clearance.
- Lytic therapy surpasses heparin in managing PE, offering improved acute and long-term results.
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