Cu-Mediated C-H Thioetherification of Arenes at Room Temperature
Xing Wang1,2, Xing Yi3, Hui Xu1,2
1Chinese Academy of Sciences Key Laboratory of Receptor Research , Shanghai Institute of Materia Medica , Shanghai 201203 , China.
Abstract:
Cu-mediated C-H thioetherification of arenes with ethylene sulfide has been developed using a readily removable directing group. The reaction proceeded at room temperature, and a variety of sensitive functional groups including chloro, bromo, and vinyl were well tolerated. The thiolated products could be converted to the seven-membered benzoxathiepinones derivatives by a sequence of hydrolysis-lactonization reactions.
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