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Updated: Jan 22, 2026
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The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
Published on: February 7, 2025
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Higher Coated-Platelet Levels in Acute Stroke are Associated with Lower Cognitive Scores at Three Months Post
Angelia C Kirkpatrick1, Julie A Stoner2, George L Dale3
1Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma.
Summary
Higher levels of coated-platelets, a marker of blood clot formation, are linked to poorer cognitive function 3 months after stroke. This suggests platelet activity may impact brain recovery and cognitive health post-stroke.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Hematology
Background:
- Coated-platelets are highly procoagulant platelets activated by collagen and thrombin.
- Elevated coated-platelet levels are observed in acute stroke patients and linked to stroke recurrence.
- This study investigates the correlation between coated-platelet levels at stroke onset and cognitive function at 3 months post-infarction.
Purpose of the Study:
- To determine if coated-platelet levels measured during acute stroke predict cognitive impairment at 3 months.
- To explore the association between platelet procoagulant potential and cognitive outcomes after cerebral infarction.
Main Methods:
- Coated-platelet levels were measured in patients with nonlacunar stroke.
- Cognitive function was assessed using the Mini-Mental State Examination (MMSE) at 3 months post-discharge.
- Linear regression models were employed to analyze the relationship between coated-platelet levels and MMSE scores, adjusting for covariates.
Main Results:
- A significant inverse linear association was found between coated-platelet levels and MMSE scores (r = -.34, P < .0001).
- Higher coated-platelet levels were predictive of lower MMSE scores, even after adjusting for confounding factors.
- Hypertension and anticoagulant use also predicted lower MMSE scores.
Conclusions:
- Increased platelet procoagulant potential at the time of stroke is associated with cognitive impairment following cerebral infarction.
- These findings highlight a potential role for platelet activity in post-stroke cognitive decline.
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