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HDL-C and non-HDL-C levels are associated with anthropometric and biochemical parameters

Sandra Maria Barbalho1,2, Ricardo José Tofano1, Marcela Bueno de Oliveira1

  • 1Universidade de Marília - UNIMAR, Faculdade de Medicina, Departamento de Bioquímica e Farmacologia, Marília, SP, Brasil.

Jornal Vascular Brasileiro
|July 18, 2019
PubMed

Insights

High-density lipoprotein cholesterol (HDL-c) and non-high-density lipoprotein cholesterol (non-HDL-c) levels are linked to cardiovascular disease risk factors like obesity and insulin resistance. Further trials are needed to explore non-HDL-c as a therapeutic target.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Biochemistry

Background:

  • Dyslipidemias are established risk factors for atherosclerosis and cardiovascular diseases (CVD).
  • Non-high-density lipoprotein cholesterol (non-HDL-c) is increasingly recognized for its role in predicting CVD risk and atheroma plaque progression.
  • HDL-c and non-HDL-c are key lipid parameters influencing cardiovascular health.

Purpose of the Study:

  • To investigate the associations between HDL-c and non-HDL-c levels with anthropometric and biochemical markers.
  • To evaluate the relationship between HDL-c and non-HDL-c with Castelli risk indexes I and II.
  • To understand the clinical significance of altered HDL-c and non-HDL-c in relation to metabolic syndrome.

Main Methods:

  • A study involving 300 randomly selected individuals, categorized by normal or altered non-HDL-c values.
  • Analysis of associations between lipid profiles (HDL-c, non-HDL-c, TC, TG, LDL-c) and anthropometric measures (WC, BMI).
  • Assessment of correlations with glycemia, Castelli Indexes (CI-I, CI-II), and the prevalence of metabolic syndrome (MS).

Main Results:

  • Significant differences in glycemia, TC, TG, LDL-c, CI-I, CI-II, WC, and BMI were observed between groups with normal and altered HDL-c and non-HDL-c.
  • Higher TC and WC values were noted in patients with abnormal non-HDL-c compared to those with abnormal HDL-c.
  • A significant difference in the occurrence of MS was found in individuals with altered HDL-c and non-HDL-c levels.

Conclusions:

  • Both HDL-c and non-HDL-c are significantly associated with insulin resistance, dyslipidemia, atherogenic indices, and obesity.
  • The findings highlight the clinical relevance of monitoring both HDL-c and non-HDL-c for cardiovascular risk assessment.
  • Further randomized clinical trials are warranted to explore the potential of non-HDL-c as a primary therapeutic target for CVD prevention.
Abstract

Keywords:
dyslipidemiaglycemiametabolic syndromenon-HDL-c

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