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Updated: Jan 22, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
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Published on: September 20, 2015

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Evaluation of quantitative CMR perfusion imaging by comparison with simultaneous 15O-water-PET

Tanja Kero1,2, Edvin Johansson3, Mathias Engström4

  • 1Medical Imaging Centre, Uppsala University Hospital, 75185, Uppsala, Sweden. tanja.kero@radiol.uu.se.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|July 18, 2019
PubMed
Abstract

Insights

Dynamic contrast-enhanced MRI (DCE MRI) shows strong correlation with 15O-water PET for measuring myocardial blood flow (MBF). However, moderate agreement suggests DCE MRI is not yet ready for clinical use in quantitative MBF assessment.

Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Radiology

Background:

  • Assessing quantitative accuracy of cardiac perfusion measurements.
  • Utilizing dynamic contrast-enhanced MRI (DCE MRI).
  • Employing simultaneous 15O-water PET as a reference standard.

Purpose of the Study:

  • To evaluate the quantitative accuracy of DCE MRI for cardiac perfusion.
  • To compare DCE MRI measurements with 15O-water PET.
  • To determine the readiness of DCE MRI for clinical introduction in MBF assessment.

Main Methods:

  • Simultaneous DCE MRI and 15O-water PET scans in 15 patients.
  • Scans performed at rest and during adenosine stress.
  • Correlation and Bland-Altman analysis for global and regional MBF values.

Main Results:

  • Strong correlations (r=0.86 global, r=0.75 regional) between MRI- and PET-based MBF.
  • Negligible bias for both global and regional MBF comparisons.
  • Wide limits of agreement and increased variability at higher MBF values.

Conclusions:

  • DCE MRI demonstrates strong correlation with 15O-water PET for MBF.
  • Moderate agreement between the two methods indicates limitations.
  • MRI-based quantitative MBF measurements require further validation before clinical adoption.
Keywords:
Myocardial perfusioncardiac magnetic resonance imagingmyocardial blood flowpositron emission tomographyquantitative modelling

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