Related Experiment Video

Updated: Jan 22, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

25.1K

Decannulation in children affected by congenital central hypoventilation syndrome: A proposal of an algorithm from

Maria Giovanna Paglietti1, Federica Porcaro1, Aleksandar Sovtic2

  • 1Pediatric Pulmonology & Respiratory Intermediate Care Unit, Sleep and Long-Term Ventilation Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, Rome, Italy.

Pediatric Pulmonology
|July 18, 2019
PubMed

Insights

Decannulation from invasive mechanical ventilation (IMV) is achievable for children with congenital central hypoventilation syndrome (CCHS). Transitioning to noninvasive ventilation (NIV) and decannulation can be successfully managed with a proposed algorithm.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Critical Care

Background:

  • Congenital central hypoventilation syndrome (CCHS) necessitates long-term ventilatory support for survival in pediatric patients.
  • Invasive mechanical ventilation (IMV) via tracheostomy is standard but carries risks like impaired speech and airway infections.
  • Limited data exists on transitioning CCHS patients from IMV to noninvasive ventilation (NIV) and decannulation.

Purpose of the Study:

  • To report the experience of a decannulation program in CCHS-affected children.
  • To propose an algorithm for transitioning CCHS patients from IMV to NIV.

Main Methods:

  • Retrospective study of four CCHS patients from two European centers undergoing tracheostomy removal.
  • Pre-decannulation training included tracheostomy capping and endoscopic airway assessment.
  • Initiation of NIV training at a mean age of 106.25 months.

Main Results:

  • Decannulation was successfully achieved in all four patients 12 months post-training.
  • No patient required reintroduction of the tracheal cannula during short or long-term follow-up.
  • Endoscopic assessment confirmed upper and lower airway suitability for decannulation.

Conclusions:

  • Effective liberation from IMV, transition to NIV, and decannulation are feasible in CCHS children.
  • The study offers a practical algorithm for selected centers to manage decannulation in CCHS patients.
Abstract

Keywords:
Ondine syndromecentral hypoventilationchildrennoninvasive ventilation

More Related Videos

Establishment of Central Cord Syndrome Model in C57BL/6J Mouse06:36

Establishment of Central Cord Syndrome Model in C57BL/6J Mouse

Published on: September 8, 2023

1.1K
Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome05:12

Portable Thermographic Screening for Detection of Acute Wallenberg's Syndrome

Published on: September 19, 2019

7.0K

Related Concept Videos

Tracheostomy Decannulation01:21

Tracheostomy Decannulation

Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
1.3K
Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
11.4K
Measures of Central Tendency02:16

Measures of Central Tendency

The "center" of a data set is also a way of describing location. The two most widely used measures of the "center" of the data are the mean (average) and the median. The words "mean" and "average" are often used interchangeably. The substitution of one word for the other is common practice. The technical term is "arithmetic mean" and "average" is technically a center location. However, in practice among non-statisticians,...
20.2K
The Central Dogma01:25

The Central Dogma

Overview
139.0K
Center of Gravity00:58

Center of Gravity

The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.6K
Center of Gravity01:15

Center of Gravity

The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
2.1K