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Related Experiment Video

Updated: Jan 22, 2026

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Current Enhancement in Solid-State Nanopores Depends on Three-Dimensional DNA Structure.

Vivian Wang¹, Niklas Ermann¹, Ulrich F Keyser¹

¹Cavendish Laboratory , University of Cambridge , 19 JJ Thomson Avenue , Cambridge CB3 0HE , United Kingdom.

|July 18, 2019

Summary

DNA translocation through nanopores shows concentration-dependent current changes. Bundled DNA nanostructures exhibit a lower crossover ionic concentration, impacting ion transport and nanopore sensing development.

Keywords:

DNA nanotechnology Nanopores ionic current single-molecule sensing

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Area of Science:

Nanotechnology
Biophysics
Materials Science

Background:

Ionic current through solid-state nanopores is sensitive to DNA translocation.
The ionic concentration of the solution dictates whether DNA translocation causes current blockade or enhancement.
Understanding ion-molecule interactions in confined geometries is crucial for nanopore applications.

Purpose of the Study:

To investigate the ionic concentration-dependent translocation behavior of bundled DNA nanostructures.
To explore the influence of molecular structure on counterion mobility near DNA.
To assess the effect of neutral polymers on DNA translocation at low salt concentrations.

Main Methods:

Solid-state nanopore measurements of double-stranded DNA and bundled DNA nanostructures.
Systematic variation of ionic concentrations in the surrounding solution.
Introduction of neutral polymers (polyethylene glycol) to modify solution properties.

Main Results:

The crossover ionic concentration for bundled DNA nanostructures is lower than for double-stranded DNA.
Reduced counterion mobility near DNA is suggested, dependent on the molecule's 3D structure.
Polyethylene glycol addition facilitated translocation of large DNA structures at low salt concentrations by reducing electroosmotic outflow.

Conclusions:

The 3D structure of DNA nanostructures significantly influences ion transport dynamics in nanopores.
Modulating solution properties with neutral polymers can enhance nanopore translocation capabilities.
These findings advance the understanding of confined ion transport, aiding nanopore sensing and synthetic channel development.