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Coumarin-Based Small-Molecule Fluorescent Chemosensors

Duxia Cao¹, Zhiqiang Liu², Peter Verwilst³

¹Institute of Fluorescent Probes for Biological Imaging, School of Materials Science and Engineering, School of Chemistry and Chemical Engineering , University of Jinan , Jinan 250022 , China.

Chemical Reviews

|July 18, 2019

Summary

Coumarin derivatives are versatile fluorescent molecules. This review highlights their progress in developing advanced small-molecule fluorescent chemosensors for diverse scientific applications.

Area of Science:

Organic Chemistry
Analytical Chemistry
Materials Science

Background:

Coumarins, defined by the 2H-chromen-2-one motif, are abundant natural compounds.
Thousands of coumarin derivatives exist, synthesized or isolated from nature.
The coumarin scaffold offers biocompatibility, stable fluorescence, and structural flexibility.

Purpose of the Study:

To review the advancements in coumarin-based small-molecule fluorescent chemosensors.
To cover the progress made between 2012 and 2018.
To provide a foundation for future chemosensor development.

Main Methods:

Literature review of coumarin-based fluorescent chemosensors.
Focus on applications in molecular recognition, imaging, and analytical chemistry.
Analysis of studies published from 2012 to 2018.

Main Results:

Coumarin derivatives are increasingly utilized in designing fluorescent chemosensors.
These sensors demonstrate broad applications in various scientific fields.
Significant progress has been achieved in their development and application.

Conclusions:

Coumarin-based fluorescent chemosensors are powerful tools in scientific research.
Their unique properties facilitate advancements in molecular recognition and imaging.
Continued development promises even broader and more exciting future applications.

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