Functional residual capacity as a noninvasive indicator of optimal positive end-expiratory pressure

We hypothesized that functional residual capacity (FRC) could be used as a noninvasive indicator of "optimal" positive end-expiratory pressure (PEEP), the level of PEEP that results in venous admixture below 15% with an inspired oxygen fraction less than 0.5. We compared several variables for PEEP optimization--oxygen transport, total respiratory system compliance, FRC-based compliance, mixed venous oxygen saturation, end-tidal to arterial carbon dioxide tension difference, and arterial oxygen saturation--by producing four different PEEP levels, 0, 5, 10 and 15 cm H2O, in 24 mongrel dogs in which pulmonary injury was produced. The data were regressed versus PEEP by using analysis of variance for regression. Venous admixture (F1,23 = 149.3; P less than 0.0001), end-tidal to arterial carbon dioxide tension difference (F1,23 = 64.9; P less than 0.0001), and oxygen transport (F1,23 = 95.1; P less than 0.0001) decreased linearly with PEEP. FRC (F1,23 = 248.1; P less than 0.0001) and arterial oxygen saturation (F1,23 = 66.9; P less than 0.0001) increased linearly with PEEP. Total respiratory system compliance (F1,23 = 66.6; P less than 0.0001) and mixed venous oxygen saturation (F1,23 = 12.2; P less than 0.002) had a quadratic relationship with respect to PEEP with a peak at 5 cm H2O. FRC-based compliance did not have a significant relationship to PEEP. The maximum values of total respiratory system compliance, FRC-based compliance, mixed venous oxygen saturation, and oxygen transport did not occur at PEEP levels that corresponded to a venous admixture below 15% ("optimal" PEEP).(ABSTRACT TRUNCATED AT 250 WORDS)