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Updated: Jan 22, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
The ADP-Ribosylating Toxins of Salmonella
Rachel A Cheng1, Martin Wiedmann2
1Department of Food Science, Cornell University, Ithaca, NY 14853, USA. ram524@cornell.edu.
Abstract:
A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen Salmonella is one of the most important and well-studied bacterial pathogens. Recently, whole genome sequence characterizations revealed the presence of multiple novel ADP-ribosylating toxins encoded by a variety of Salmonella serovars. In this review, we discuss both the classical (SpvB) and novel (typhoid toxin, ArtAB, and SboC/SeoC) ADP-ribosylating toxins of Salmonella, including the structure and function of these toxins and our current understanding of their contributions to virulence.
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