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TRP Channels Expression Profile in Human End-Stage Heart Failure

Martin Dragún1, Andrea Gažová2, Ján Kyselovič3

  • 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University in Bratislava, Odbojarov 10, 83232 Bratislava, Slovakia.

Medicina (Kaunas, Lithuania)
|July 19, 2019
PubMed

Insights

End-stage heart failure shows altered expression of transient receptor potential (TRP) channels in human heart muscle. This study systematically maps these changes, revealing specific TRP channel alterations in failing myocardium.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Physiology

Background:

  • Transient receptor potential (TRP) channels are implicated in cardiac hypertrophy, but data from human studies are limited and conflicting.
  • Previous research primarily utilized animal models, necessitating investigation in human failing myocardium.

Purpose of the Study:

  • To systematically analyze the expression of TRP channels (TRPC, TRPM, TRPV) in human failing heart tissue.
  • To identify specific TRP channel expression patterns associated with end-stage heart failure.
  • To correlate TRP channel expression with clinical and functional parameters in heart failure patients.

Main Methods:

  • Quantitative real-time PCR was used to measure mRNA levels of TRPC, TRPM, and TRPV channels.
  • Left-ventricular myocardial tissue was obtained from heart transplant recipients (NYHA III-IV) and healthy donors.
  • Clinical, functional, and biochemical data were analyzed to confirm heart failure diagnosis.

Main Results:

  • Significant upregulation of TRPC1, TRPC5, TRPM4, and TRPM7 mRNA was observed in failing myocardium compared to controls.
  • Decreased expression of TRPC4 and TRPV2 mRNA was detected in heart failure patients.
  • TRP channel expression changes were independent of gender, clinical, or functional parameters, but TRPC1 correlated with MEF2c expression.

Conclusions:

  • End-stage human heart failure is characterized by distinct alterations in TRP channel expression profiles.
  • This study provides a comprehensive description of TRP channel expression in the failing human heart.
  • Further research is needed to elucidate the role of TRP channels in early stages of cardiac hypertrophy and heart failure progression.

Keywords:
TRP channelscalcium signalingheart failurehuman

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