Related Experiment Video

Updated: Jan 22, 2026

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

17.0K

[Correlation between gut microbiota and behavior symptoms in children with autism spectrum disorder]

Rui-Hao Zhao1, Peng-Yuan Zheng, Si-Meng Liu

  • 1Department of Gastroenterology, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. medp7123@126.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|July 19, 2019
PubMed

Insights

Autism spectrum disorder (ASD) is linked to gut bacteria differences. Specific bacteria like Megamonas correlate with behavior symptoms in children with ASD, suggesting a gut-brain connection.

Area of Science:

  • Microbiology
  • Neuroscience
  • Genetics

Background:

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental condition.
  • Gut microbiota plays a crucial role in host health and behavior.
  • Altered gut microbiota composition has been observed in various neurodevelopmental disorders.

Purpose of the Study:

  • To investigate the gut microbiota composition in children with ASD.
  • To explore the correlation between gut microbiota and the severity of behavioral symptoms in ASD.
  • To identify specific bacterial taxa associated with ASD-related behaviors.

Main Methods:

  • Compared gut microbiota composition between 30 children with ASD and 20 healthy controls using 16S rRNA gene sequencing.
  • Assessed behavioral symptoms using the Autism Behavior Checklist.
  • Employed Spearman's correlation analysis to link microbiota and behavior.

Main Results:

  • Significant differences in gut microbiota diversity and composition were found between ASD and control groups.
  • ASD group showed reduced Shannon and Shannoneven indices, lower Firmicutes, and higher Acidobacteria.
  • Megamonas abundance positively correlated with health/physical/behavior and language communication scores in ASD children.

Conclusions:

  • Gut microbiota composition is significantly associated with ASD development.
  • Specific bacterial alterations in the gut may contribute to the severity of behavioral symptoms in ASD.
  • Findings suggest a potential role for gut microbiota modulation in managing ASD.
Abstract

More Related Videos

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.6K
A Semantic Priming Event-related Potential ERP Task to Study Lexico-semantic and Visuo-semantic Processing in Autism Spectrum Disorder08:17

A Semantic Priming Event-related Potential ERP Task to Study Lexico-semantic and Visuo-semantic Processing in Autism Spectrum Disorder

Published on: April 12, 2018

11.1K

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.0K
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
1.5K
Correlations02:20

Correlations

Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
The Electromagnetic Spectrum02:37

The Electromagnetic Spectrum

The electromagnetic spectrum consists of all the types of electromagnetic radiation arranged according to their frequency and wavelength. Each of the various colors of visible light has specific frequencies and wavelengths associated with them, and you can see that visible light makes up only a small portion of the electromagnetic spectrum. Because the technologies developed to work in various parts of the electromagnetic spectrum are different, for reasons of convenience and historical...
64.8K
The Electromagnetic Spectrum01:24

The Electromagnetic Spectrum

Electromagnetic waves are categorized according to their wavelengths and frequencies, giving the electromagnetic spectrum. These waves are classified as radio, infrared, ultraviolet, etc. Radio waves refer to electromagnetic radiation with wavelengths ranging from millimeters to kilometers. Radio waves are commonly used for audio communications (i.e., radios) and typically result from an alternating current in the wires of a broadcast antenna. They cover a broad wavelength range and are used...
33.3K
Correlation and Causation01:27

Correlation and Causation

Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.1K