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Survival Following Salvage Surgery after Failed Radiotherapy for Penile Cancer: A SEER-Based Study
Mahmoud I Khalil1,2, Fei Wan3, Ehab Eltahawy1,2
1Department of Urology, University of Arkansas for Medical Sciences, Little Rock, AR.
Current Urology
|July 19, 2019
Summary
Salvage surgery following radiation therapy for penile cancer shows poor survival outcomes. Most patients died within the first year, with only a third surviving up to three years post-surgery.
Area of Science:
- Oncology
- Surgical Oncology
- Radiation Oncology
Background:
- Salvage surgery (SS) is a treatment option for local failure in penile cancer (PC) after radiation therapy (RT).
- Limited data exists on the survival outcomes of patients undergoing SS for PC post-RT.
Purpose of the Study:
- To evaluate the survival outcomes of salvage surgery in patients with penile cancer who experienced treatment failure following radiation therapy.
Main Methods:
- A retrospective analysis of the Surveillance, Epidemiology, and End Results (SEER) database was conducted.
- Patients who underwent SS for PC after RT between 1976 and 2013 were identified.
- Demographic, social, and pathological data were collected, and 1-, 3-, 5-, and 10-year survival rates were calculated.
Main Results:
- Seventeen patients received penile SS post-RT. The majority (94.12%) had squamous cell carcinoma and received external beam radiation.
- Overall survival rates at 1, 3, 5, and 10 years were 68.8%, 35.7%, 35.7%, and 10.7%, respectively.
- Cancer-specific survival rates at 1, 3, 5, and 10 years were 72.7%, 48.4%, 48.4%, and 36.3%, respectively.
Conclusions:
- Salvage surgery for penile cancer following radiation therapy failure is associated with poor overall survival.
- A significant proportion of patients (nearly one-third) died within the first year after salvage surgery.
- Long-term survival remains limited, with only about one-third of patients surviving for three years post-salvage surgery.
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