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Neurodisability with Severe Restriction of Mobility Is Associated with Reduced Serum Creatinine Values

Chun Lim1, Marianne Phillips1, Liam Watson1

  • 1Luton&Dunstable University Hospital NHS Foundation Trust, Lewsey Road, Luton, LU4ODZ, UK.

International Journal of Pediatrics
|July 19, 2019
PubMed

Insights

Reduced mobility in children with neurodisability is linked to lower serum creatinine levels. Severe mobility impairment, particularly in those who died, showed significantly decreased creatinine compared to controls.

Area of Science:

  • Pediatric Neurology
  • Biochemistry
  • Clinical Research

Background:

  • Neurodisability can impact various physiological markers.
  • Serum creatinine is a marker of muscle mass and kidney function.
  • The relationship between mobility and serum creatinine in children with neurodisability requires investigation.

Purpose of the Study:

  • To determine if reduced mobility correlates with lower serum creatinine in children with neurodisability.
  • To compare serum creatinine levels across different Gross Motor Function Classification System (GMFCS) levels and with healthy controls.

Main Methods:

  • Retrospective record-based study design.
  • Comparison of serum creatinine levels in children with neurodisability (GMFCS categories 1-3 and 4-5) against age-matched controls.
  • Statistical analysis to identify significant differences in creatinine levels between groups.

Main Results:

  • Children with neurodisability had significantly lower serum creatinine than controls (p=0.002).
  • Children with severe mobility restriction (GMFCS IV-V) exhibited significantly lower creatinine levels compared to controls and those with milder impairment (p<0.001).
  • Lower creatinine levels were observed in deceased children with severe neurodisability compared to survivors (p=0.04).

Conclusions:

  • Severe mobility restriction in children with neurodisability is associated with significantly reduced serum creatinine.
  • Lower serum creatinine levels may be a potential indicator in severe neurodisability, particularly in cases of mortality.
Abstract

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