Related Experiment Video

Updated: Jan 22, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

5.2K

Subcutaneous Immunoglobulin in Infantile Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report

Paola Cianci1, Silvia Salvatore1, Alex Moretti1

  • 1Woman and Child Department, Ospedale "F. Del Ponte," University of Insubria, Varese, Italy.

Journal of Pediatric Neurosciences
|July 19, 2019
PubMed

Insights

Subcutaneous immunoglobulins (SCIgs) offer a promising alternative for pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) management. This approach improved a young patient

Area of Science:

  • Neurology
  • Immunology

Background:

  • Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, antibody-mediated sensorimotor disorder in children.
  • Current pediatric CIDP treatments lack robust evidence-based efficacy and can be challenging to administer.
  • Intravenous immunoglobulins (IVIgs) are common but often uncomfortable for pediatric patients.

Observation:

  • A 7-year-old boy with CIDP showed clinical response to IVIg but required ongoing treatment.
  • The patient's quality of life was impacted by the need for IVIg therapy.

Findings:

  • Switching the pediatric CIDP patient from IVIg to subcutaneous immunoglobulins (SCIgs) resulted in an excellent clinical outcome.
  • SCIgs demonstrated effectiveness in this case, mirroring findings in adults and other pediatric immune disorders.

Implications:

  • Subcutaneous immunoglobulins (SCIgs) represent a viable and potentially more comfortable alternative for managing pediatric CIDP.
  • This case highlights the potential of SCIgs to improve treatment adherence and quality of life in children with CIDP.
  • Further research into SCIgs for pediatric CIDP is warranted to establish evidence-based guidelines.

Keywords:
CIDPChildrenchronic inflammatory demyelinating polyneuropathyintravenous immunoglobulinssubcutaneous immunoglobulins

More Related Videos

Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain08:20

Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain

Published on: June 30, 2023

2.7K
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

22.3K

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.1K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.2K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.5K
Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
Types of Reports I: Hands-off Report01:25

Types of Reports I: Hands-off Report

A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K
Types of Reports II: Incident or Occurrence Report01:21

Types of Reports II: Incident or Occurrence Report

An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.2K